唾液腺超声检查可用于诊断原发性干燥综合征
发表者：李常虹
日期：2015-03-05
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摘要（塞尔维亚）：目的：评价用大唾液腺超声检查取代唾液腺造影后修订的美国-欧洲原发性干燥综合征（pSS）分类标准（AEC）诊断pSS的准确度。
方法：包括做过唾液腺超声检查在内的190例研究对象用于评估诊断pSS的准确性。我们评价了三套不同pSS诊断标准的准确性。每套诊断标准均包括眼部症状，口腔症状，Schirmer-I 试验及SSA抗体四条和以下中的任意一条：唾液腺超声检查(US set)，唾液腺造影(sSC set)或活检(Biopsy set)。ROC曲线下面积用于评估每套标准诊断的准确性。
结果：190例研究对象中有140例符合pSS的AEC诊断标准，而另外50例研究对象被归类为非pSS患者。在这140例pSS患者中有129 (92%)例唾液腺超声检查阳性，123 (88%)例唾液腺造影阳性和93 (66%)例活检阳性。此外，140例pSS患者中有88 (63%)例患者满足US set诊断标准，有85 (61%)例患者满足sSC set诊断标准和71 (51%) 例患者满足Biopsy set诊断标准。被归类为非pSS患者的50例研究对象中无一例满足以上任何一套pSS诊断标准。三套诊断标准的准确性均很高且非常相近，相应的ROC曲线下面积分别为US set 0.99 (0.00)，sSC set 0.98 (0.00)和Biopsy set 0.97 (0.00)。
结论：在美国-欧洲原发性干燥综合征（pSS）分类标准中，能够用大唾液腺的超声检查取代唾液腺造影用于诊断pSS。
附原文：Abstract Objective. To test the diagnostic accuracy of modified American-[1]European classification criteria (AEC) for primary SS (pSS) by replacing sialoscintigraphy (sSC) with ultrasonography of the major salivary glands.Methods. One hundred and ninety subjects were evaluated for the diagnosis of pSS, including US of the salivary glands. We tested the diagnostic accuracy of the three different sets of five diagnostic criteria for pSS. Each set combined these four criteria (ocular symptoms, oral symptoms, Schirmer-I test and auto-SS-A antibody) and one of the following: US (US set), sSC (sSC set) or biopsy (Biopsy set). The area under the receiver operating characteristics curve (AUC-ROC) was used to evaluate the diagnostic accuracy of each set of criteria.Results. Out of 190 subjects examined, 140 subjects fulfilled the AEC for the diagnosis of pSS, whereas 50 subjects were classified as non-pSS subjects. US score was positive in 129 (92%), sSC in 123 (88%) and biopsy in 93 (66%) of 140 pSS patients. Among 140 patients with pSS, 88 (63%) patients fulfilled the criteria of the US set, 85 (61%) patients of the sSC set and 71 (51%) patients of the Biopsy set. None of the subjects from the non-pSS group fulfilled any of the sets of criteria. Diagnostic accuracy of each of the three sets of criteria was high and similar [AUC-ROC (S.E.) for the US set was 0.99 (0.00), followed by the sSC set at 0.98 (0.00) and the Biopsy set at 0.97 (0.00)].Conclusion. US finding of major salivary gland involvement could replace sSC in AEC for the diagnosis of pSS.
引自：Ultrasonography of major salivary glands could be an alternative tool to sialoscintigraphy in the American[1]European classification criteria for primary Sjogren’s syndrome.Vera Milic, Radmila Petrovic, Ivan Boricic, Goran Radunovic, Jelena Marinkovic-Eric, Predrag Jeremic, Nemanja Damjanov.Rheumatology. 2012, （注：干燥综合症病人或亲属可加QQ群交流，群号： 118194945 ，本网站站长私人微信号： ssgzz88 ）
方法：包括做过唾液腺超声检查在内的190例研究对象用于评估诊断pSS的准确性。我们评价了三套不同pSS诊断标准的准确性。每套诊断标准均包括眼部症状，口腔症状，Schirmer-I 试验及SSA抗体四条和以下中的任意一条：唾液腺超声检查(US set)，唾液腺造影(sSC set)或活检(Biopsy set)。ROC曲线下面积用于评估每套标准诊断的准确性。
结果：190例研究对象中有140例符合pSS的AEC诊断标准，而另外50例研究对象被归类为非pSS患者。在这140例pSS患者中有129 (92%)例唾液腺超声检查阳性，123 (88%)例唾液腺造影阳性和93 (66%)例活检阳性。此外，140例pSS患者中有88 (63%)例患者满足US set诊断标准，有85 (61%)例患者满足sSC set诊断标准和71 (51%) 例患者满足Biopsy set诊断标准。被归类为非pSS患者的50例研究对象中无一例满足以上任何一套pSS诊断标准。三套诊断标准的准确性均很高且非常相近，相应的ROC曲线下面积分别为US set 0.99 (0.00)，sSC set 0.98 (0.00)和Biopsy set 0.97 (0.00)。
结论：在美国-欧洲原发性干燥综合征（pSS）分类标准中，能够用大唾液腺的超声检查取代唾液腺造影用于诊断pSS。
附原文：Abstract Objective. To test the diagnostic accuracy of modified American-[1]European classification criteria (AEC) for primary SS (pSS) by replacing sialoscintigraphy (sSC) with ultrasonography of the major salivary glands.Methods. One hundred and ninety subjects were evaluated for the diagnosis of pSS, including US of the salivary glands. We tested the diagnostic accuracy of the three different sets of five diagnostic criteria for pSS. Each set combined these four criteria (ocular symptoms, oral symptoms, Schirmer-I test and auto-SS-A antibody) and one of the following: US (US set), sSC (sSC set) or biopsy (Biopsy set). The area under the receiver operating characteristics curve (AUC-ROC) was used to evaluate the diagnostic accuracy of each set of criteria.Results. Out of 190 subjects examined, 140 subjects fulfilled the AEC for the diagnosis of pSS, whereas 50 subjects were classified as non-pSS subjects. US score was positive in 129 (92%), sSC in 123 (88%) and biopsy in 93 (66%) of 140 pSS patients. Among 140 patients with pSS, 88 (63%) patients fulfilled the criteria of the US set, 85 (61%) patients of the sSC set and 71 (51%) patients of the Biopsy set. None of the subjects from the non-pSS group fulfilled any of the sets of criteria. Diagnostic accuracy of each of the three sets of criteria was high and similar [AUC-ROC (S.E.) for the US set was 0.99 (0.00), followed by the sSC set at 0.98 (0.00) and the Biopsy set at 0.97 (0.00)].Conclusion. US finding of major salivary gland involvement could replace sSC in AEC for the diagnosis of pSS.
引自：Ultrasonography of major salivary glands could be an alternative tool to sialoscintigraphy in the American[1]European classification criteria for primary Sjogren’s syndrome.Vera Milic, Radmila Petrovic, Ivan Boricic, Goran Radunovic, Jelena Marinkovic-Eric, Predrag Jeremic, Nemanja Damjanov.Rheumatology. 2012, （注：干燥综合症病人或亲属可加QQ群交流，群号： 118194945 ，本网站站长私人微信号： ssgzz88 ）