抗CCP抗体是干燥综合征进展为类风湿关节炎的独立危险因素
发表者：郑晓娟
日期：2015-03-04
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摘要：抗CCP抗体对于诊断RA很有帮助，临床上抗CCP抗体和RA关节破坏有关。有文献报道抗CCP抗体诊断类风湿关节炎的特异性高达95%。因为它如此特异，我们总结了抗CCP抗体阳性的干燥综合征患者的临床特点。总共405例干燥综合征的患者，平均随访60个月，23 (5.6 %)的患者进展为类风湿关节炎。比较抗CCP阳性和CCP阴性两组患者，发现关节痛和关节炎在两组间存在明显差异。多因素结果分析显示，抗CCP抗体阳性是干燥综合征患者进展为RA的独立的危险因素，OR值为2.5 (95 % CI 1.7-3.7)。对于有关节炎的原发性干燥综合征患者进行CCP抗体的检测有利于预测原发性干燥综合征的患者是否会进展为类风湿关节炎。
附原文：Anti-cyclic citrullinated peptide antibody (anti-CCP antibody) is very useful for the diagnosis of rheumatoid arthritis (RA) and is associated with articular erosions. The specificity of anti-CCP antibody in the diagnosis of RA has been reported to be about 95 %. Because of its higher specificity in RA, we assessed the clinical features of primary Sjogren's syndrome (pSS) who were positive for anti-CCP antibody. We assessed the clinical features of 405 pSS patients. After 60 (range 7-98) months, 23 (5.6 %) patients previously diagnosed with pSS had progressed to RA. Comparing the anti-CCP positive group with the negative group, laboratory test results for anti-CCP titer and rheumatoid factor positivity with respect to clinical outcome and progression to RA, arthralgia and arthritis were significantly different. Multivariate regression analysis also showed that anti-CCP antibody titer was independently associated with progression to RA. The odds ratio of anti-CCP positivity in terms of progression to RA was 2.5 (95 % CI 1.7-3.7). Testing for anti-CCP antibody in pSS patients with arthritis may allow for the prediction of progression to RA.
引自：Ryu YS, Park SH, Lee J, et al. Follow-up of primary Sjogren's syndrome patients presenting positive anti-cyclic citrullinated peptides antibody.Rheumatol Int. 2013 Jun;33(6):1443-6. doi: 10.1007/s00296-012-2572-4. Epub 2012 Nov 21. （注：干燥综合症病人或亲属可加QQ群交流，群号： 118194945 ，本网站站长私人微信号： ssgzz88 ）
附原文：Anti-cyclic citrullinated peptide antibody (anti-CCP antibody) is very useful for the diagnosis of rheumatoid arthritis (RA) and is associated with articular erosions. The specificity of anti-CCP antibody in the diagnosis of RA has been reported to be about 95 %. Because of its higher specificity in RA, we assessed the clinical features of primary Sjogren's syndrome (pSS) who were positive for anti-CCP antibody. We assessed the clinical features of 405 pSS patients. After 60 (range 7-98) months, 23 (5.6 %) patients previously diagnosed with pSS had progressed to RA. Comparing the anti-CCP positive group with the negative group, laboratory test results for anti-CCP titer and rheumatoid factor positivity with respect to clinical outcome and progression to RA, arthralgia and arthritis were significantly different. Multivariate regression analysis also showed that anti-CCP antibody titer was independently associated with progression to RA. The odds ratio of anti-CCP positivity in terms of progression to RA was 2.5 (95 % CI 1.7-3.7). Testing for anti-CCP antibody in pSS patients with arthritis may allow for the prediction of progression to RA.
引自：Ryu YS, Park SH, Lee J, et al. Follow-up of primary Sjogren's syndrome patients presenting positive anti-cyclic citrullinated peptides antibody.Rheumatol Int. 2013 Jun;33(6):1443-6. doi: 10.1007/s00296-012-2572-4. Epub 2012 Nov 21. （注：干燥综合症病人或亲属可加QQ群交流，群号： 118194945 ，本网站站长私人微信号： ssgzz88 ）