干燥综合征外周感觉神经病变与抗SSA抗体有关
发表者：刘蕊
日期：2015-03-04
浏览次数：219
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摘要 背景：干燥综合征是一种常见的慢性自身免疫性疾病,通常因炎症导致唾液腺、泪腺功能下降。其他器官也可受累,包括神经系统。感觉周围神经病变是该病的一种常见表现。
方法:八十八名患者参加眼-口干门诊检查被诊断为原发性干燥综合征并接受神经系统检查。Anti-Ro(或SSA)和anti-La(或SSB)测定使用免疫扩散以及BioPlex ANA screen。血清维生素B12水平测定使用酶联免疫微量滴定板检测。
结果: 88患者中有27(31%)例存在的周围神经病变，即轻触觉或本体感受或振动觉异常。免疫扩散发检查发现12例抗-Ro和抗-La阳性,其中有神经病变的患者8例，和抗体阴性的患者相比χ(2) = 8.46, P = 0.0036, OR值= 6.0。免疫扩散检测仅存在抗-Ro阳性的27例患者,13例(48.1%)有神经病变(χ(2)= 5.587,P = 0.018,和没有抗-Ro抗体的患者相比)，与其他的没有关系,抗-Ro和抗-La抗体同时存在更敏感的提示存在神经病变。此外,我们没有发现血清维生素B 12水平与干燥综合征神经病变的相关性。
结论:感觉周围神经病变在干燥综合征患者中比较常见，而且和与免疫扩散法检测抗-Ro和抗-La抗体同时存在相关。
附原文：BACKGROUND: Sjögren syndrome is a common, chronic autoimmune disease that typically produces inflammation and poor function of the salivary and lacrimal glands. Other organs can be affected, including the nervous system. Sensory peripheral neuropathy is a common manifestation of the disease.METHODS: Eight-eight patients attending a dry eyes-dry mouth clinic were diagnosed to have primary Sjögren syndrome and underwent a neurological examination. Anti-Ro (or SSA) and anti-La (or SSB) were determined using immunodiffusion as well as Inno-Lia and BioPlex ANA screen. Serum vitamin B(12) levels were determined using an enzyme-linked microtiter plate assay.RESULTS: Twenty-seven (31%) of the 88 patients had peripheral neuropathy as defined by loss of light touch, proprioception, or vibratory sensation. Anti-Ro and anti-La were found by immunodiffusion in 12 patients, and 8 of these 12 had neuropathy (χ(2) = 8.46, P = 0.0036, odds ratio = 6.0 compared to those without precipitating anti-Ro and anti-La). Of the 27 patients with only anti-Ro by immunodiffusion, 13 (48.1%) had neuropathy (χ(2) = 5.587, P = 0.018, compared to those without anti-Ro). There was no relationship of the other, more sensitive measures of anti-Ro and anti-La to neuropathy. In addition, we found no association of serum vitamin B(12) levels to neuropathy among these patients with Sjögren syndrome.CONCLUSIONS: Sensory peripheral neuropathy is common among patients with Sjögren syndrome and is associated with the presence of anti-Ro and anti-La when determined by immunodiffusion （注：干燥综合症病人或亲属可加QQ群交流，群号： 118194945 ，本网站站长私人微信号： ssgzz88 ）
方法:八十八名患者参加眼-口干门诊检查被诊断为原发性干燥综合征并接受神经系统检查。Anti-Ro(或SSA)和anti-La(或SSB)测定使用免疫扩散以及BioPlex ANA screen。血清维生素B12水平测定使用酶联免疫微量滴定板检测。
结果: 88患者中有27(31%)例存在的周围神经病变，即轻触觉或本体感受或振动觉异常。免疫扩散发检查发现12例抗-Ro和抗-La阳性,其中有神经病变的患者8例，和抗体阴性的患者相比χ(2) = 8.46, P = 0.0036, OR值= 6.0。免疫扩散检测仅存在抗-Ro阳性的27例患者,13例(48.1%)有神经病变(χ(2)= 5.587,P = 0.018,和没有抗-Ro抗体的患者相比)，与其他的没有关系,抗-Ro和抗-La抗体同时存在更敏感的提示存在神经病变。此外,我们没有发现血清维生素B 12水平与干燥综合征神经病变的相关性。
结论:感觉周围神经病变在干燥综合征患者中比较常见，而且和与免疫扩散法检测抗-Ro和抗-La抗体同时存在相关。
附原文：BACKGROUND: Sjögren syndrome is a common, chronic autoimmune disease that typically produces inflammation and poor function of the salivary and lacrimal glands. Other organs can be affected, including the nervous system. Sensory peripheral neuropathy is a common manifestation of the disease.METHODS: Eight-eight patients attending a dry eyes-dry mouth clinic were diagnosed to have primary Sjögren syndrome and underwent a neurological examination. Anti-Ro (or SSA) and anti-La (or SSB) were determined using immunodiffusion as well as Inno-Lia and BioPlex ANA screen. Serum vitamin B(12) levels were determined using an enzyme-linked microtiter plate assay.RESULTS: Twenty-seven (31%) of the 88 patients had peripheral neuropathy as defined by loss of light touch, proprioception, or vibratory sensation. Anti-Ro and anti-La were found by immunodiffusion in 12 patients, and 8 of these 12 had neuropathy (χ(2) = 8.46, P = 0.0036, odds ratio = 6.0 compared to those without precipitating anti-Ro and anti-La). Of the 27 patients with only anti-Ro by immunodiffusion, 13 (48.1%) had neuropathy (χ(2) = 5.587, P = 0.018, compared to those without anti-Ro). There was no relationship of the other, more sensitive measures of anti-Ro and anti-La to neuropathy. In addition, we found no association of serum vitamin B(12) levels to neuropathy among these patients with Sjögren syndrome.CONCLUSIONS: Sensory peripheral neuropathy is common among patients with Sjögren syndrome and is associated with the presence of anti-Ro and anti-La when determined by immunodiffusion （注：干燥综合症病人或亲属可加QQ群交流，群号： 118194945 ，本网站站长私人微信号： ssgzz88 ）