原发性干燥综合征未增加缺血性中风风险
发表者：刘蕊
日期：2015-02-27
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摘要：罕有针对确诊原发性干燥综合征(PSS)后出现缺血性中风风险的研究。本研究为探讨PSS是否增加缺血性卒中的风险的全国性队列研究。数据来自在台湾注册的灾难性的疾病，共收集了从2000年到2006年之间4276例新诊断PSS且此前没有中风病史的患者。每个PSS患者均有10个匹配的对照(包括年龄、性别、并发症和注册日期)，对照组资料来自纵向健康保险2000数据库中入组前没有系统性自身免疫性疾病或中风的人群。所有研究对象自登记之日起随访直到他们出现了缺血性中风,死亡,或者直到2006年底,哪个发生最早即为随访终点。应用对年龄、性别、伴发疾病校正的Cox回归模型，调查PSS是否为出现缺血性中风的独立危险因素。在4276 PSS病人和42760个对照组,669例(51 PSS病人和618个对照)出现缺血性中风的平均随访时间为3.7年(四分位范围2.2 - -5.2年)。PSS患者和对照组有着相似的发生缺血性中风的发病率(3.17/1000与3.90/1000人年)。多变量分析校正的基线协变量表明，PSS未增加缺血性中风的风险(风险调整系数:0.84,95%可信区间:0.63-1.12,P = 0.244)。PSS在确诊后不是出现缺血性中风的危险因素。
附原文：Few studies are available on the risk of ischemic stroke after a diagnosis of primary Sjögren's syndrome(PSS). This study investigated whether PSS increased the risk of ischemic stroke in a large, nationwide cohort. Data for 4,276 patients who were newly diagnosed with PSS from 2000 to 2006 and who did not have a stroke prior to diagnosis of PSS were obtained from the Registry of Catastrophic Illness in Taiwan. For each PSS patient, data for ten controls (matched by age, gender, comorbidities, and enrollment date) without systemic autoimmune disease or previous stroke were obtained from the Longitudinal Health Insurance 2000 database. All study subjects were followed up from the date of enrollment until they developed ischemic stroke, died, or until the end of 2006, whichever was earliest. To investigate if PSS was an independent factor in determining the risk of developing ischemic stroke, a Cox regression model was used with adjustment for age, gender, and comorbid disorders. Among 4,276 PSS patients and 42,760 controls, 669 subjects (51 PSS patients and 618 controls) developed ischemic stroke during the mean 3.7-year follow-up period (interquartile range 2.2-5.2 years). Patients with PSS and controls had a similar incidence of ischemic stroke occurrence (3.17/1,000 vs. 3.90/1,000 person years). Multivariate analysis adjusted for baseline covariates indicated that PSS did not increase the risk of ischemic stroke (adjusted hazard ratio: 0.84, 95 % confidence interval: 0.63-1.12, P = 0.244). PSS is not associated with an increased risk of ischemic stroke subsequent to diagnosis.
引自：Chiang CH1, Liu CJ, Chen PJ,et al. Primary Sjögren's syndrome and risk of ischemic stroke: a nationwide study. Clin Rheumatol. 2014 Mar 21 （注：干燥综合症病人或亲属可加QQ群交流，群号： 118194945 ，本网站站长私人微信号： ssgzz88 ）
附原文：Few studies are available on the risk of ischemic stroke after a diagnosis of primary Sjögren's syndrome(PSS). This study investigated whether PSS increased the risk of ischemic stroke in a large, nationwide cohort. Data for 4,276 patients who were newly diagnosed with PSS from 2000 to 2006 and who did not have a stroke prior to diagnosis of PSS were obtained from the Registry of Catastrophic Illness in Taiwan. For each PSS patient, data for ten controls (matched by age, gender, comorbidities, and enrollment date) without systemic autoimmune disease or previous stroke were obtained from the Longitudinal Health Insurance 2000 database. All study subjects were followed up from the date of enrollment until they developed ischemic stroke, died, or until the end of 2006, whichever was earliest. To investigate if PSS was an independent factor in determining the risk of developing ischemic stroke, a Cox regression model was used with adjustment for age, gender, and comorbid disorders. Among 4,276 PSS patients and 42,760 controls, 669 subjects (51 PSS patients and 618 controls) developed ischemic stroke during the mean 3.7-year follow-up period (interquartile range 2.2-5.2 years). Patients with PSS and controls had a similar incidence of ischemic stroke occurrence (3.17/1,000 vs. 3.90/1,000 person years). Multivariate analysis adjusted for baseline covariates indicated that PSS did not increase the risk of ischemic stroke (adjusted hazard ratio: 0.84, 95 % confidence interval: 0.63-1.12, P = 0.244). PSS is not associated with an increased risk of ischemic stroke subsequent to diagnosis.
引自：Chiang CH1, Liu CJ, Chen PJ,et al. Primary Sjögren's syndrome and risk of ischemic stroke: a nationwide study. Clin Rheumatol. 2014 Mar 21 （注：干燥综合症病人或亲属可加QQ群交流，群号： 118194945 ，本网站站长私人微信号： ssgzz88 ）