干燥综合征患者发声受损的危险因素
发表者：作者:Pierce JL 翻译: 李欣艺
日期：2015-02-27
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摘要 目的：干燥综合征是一种自身免疫性疾病，主要是通过累及唾液及泪腺等外分泌腺而造成干燥症状。发声异常的症状在干燥综合征患者中早有记录，但是此症状的真正流行及致病因素到目前为止还不清楚。此篇初始的流行病学研究主要是探讨干燥综合征患者发声异常的流行及危险因素。
研究设计：采用自我报告的流行病学调查问卷
方法：有101位干燥综合征患者参与其中，包括94位女性，7位男性。他们均完成一份经过验证的、涉及患者医疗、工作、心理、社会生活、发声及健康状况等方面的调查问卷。概括统计量、卡方值、危险因素、多远逻辑回归等均用于判断干燥综合征患者发声异常的频率及严重性，此外还有人口统计、生活方式、健康、疾病严重性及发声使用因素等。
结果：目前在干燥综合征患者中出现发声异常者大约有59.4%。总体上，发声异常的发生是逐渐产生的，是慢性的，并且独立于年龄、性别，与干燥综合征疾病的严重程度、自身免疫状态、干燥治疗药物相关。干燥综合征患者典型发声异常的症状包括慢性咽部疼痛、干燥，这些都与干燥综合征的严重性密切相关。
附原文：Abstract OBJECTIVES/HYPOTHESIS: Sjögren's Syndrome (SS) is an autoimmune disease that causes sicca (dryness) symptoms by affecting secretions most notably of the lacrimal and salivary glands. Voice disorders have been documented in patients with SS, but the true prevalence and relationships among possible contributing factors remain unknown. This preliminary epidemiological investigation examined prevalence and risk factors for voice disorders in SS.STUDY DESIGN: Self-report epidemiological questionnaire.METHODS: One hundred and one (101) patients with SS (94 females, 7 males; M age = 59.4 years; standard deviation [SD] = 14.1 years) completed an extensive interview using a previously validated questionnaire involving the patient's medical, family, occupational, psychosocial, social/lifestyle, voice use, and general health histories. Summary statistics, chi-squares, risk ratios, and multiple logistic regression were used to determine the frequency and severity of voice disorders in individuals with SS, as well as associations with demographic, lifestyle, health, disease severity, and voice use factors.RESULTS: The prevalence of a current voice disorder in individuals with SS was 59.4%. In general, voice disorders began gradually; were chronic; and correlated with SS disease severity independent of age, sex, duration of the disease, comorbid autoimmune conditions, and use of SS-related medication. Specific voice symptoms including chronic throat dryness and soreness were significantly associated with SS disease severity.
引自：Pierce JL, Tanner K, Merrill RM, Miller KL, Ambati BK, Kendall KA, Roy N. Voice disorders in Sjögren's syndrome: Prevalence and related risk factors. Laryngoscope, 2014.© 2014 The American Laryngological, Rhinological and Otological Society, Inc. （注：干燥综合症病人或亲属可加QQ群交流，群号： 118194945 ，本网站站长私人微信号： ssgzz88 ）
研究设计：采用自我报告的流行病学调查问卷
方法：有101位干燥综合征患者参与其中，包括94位女性，7位男性。他们均完成一份经过验证的、涉及患者医疗、工作、心理、社会生活、发声及健康状况等方面的调查问卷。概括统计量、卡方值、危险因素、多远逻辑回归等均用于判断干燥综合征患者发声异常的频率及严重性，此外还有人口统计、生活方式、健康、疾病严重性及发声使用因素等。
结果：目前在干燥综合征患者中出现发声异常者大约有59.4%。总体上，发声异常的发生是逐渐产生的，是慢性的，并且独立于年龄、性别，与干燥综合征疾病的严重程度、自身免疫状态、干燥治疗药物相关。干燥综合征患者典型发声异常的症状包括慢性咽部疼痛、干燥，这些都与干燥综合征的严重性密切相关。
附原文：Abstract OBJECTIVES/HYPOTHESIS: Sjögren's Syndrome (SS) is an autoimmune disease that causes sicca (dryness) symptoms by affecting secretions most notably of the lacrimal and salivary glands. Voice disorders have been documented in patients with SS, but the true prevalence and relationships among possible contributing factors remain unknown. This preliminary epidemiological investigation examined prevalence and risk factors for voice disorders in SS.STUDY DESIGN: Self-report epidemiological questionnaire.METHODS: One hundred and one (101) patients with SS (94 females, 7 males; M age = 59.4 years; standard deviation [SD] = 14.1 years) completed an extensive interview using a previously validated questionnaire involving the patient's medical, family, occupational, psychosocial, social/lifestyle, voice use, and general health histories. Summary statistics, chi-squares, risk ratios, and multiple logistic regression were used to determine the frequency and severity of voice disorders in individuals with SS, as well as associations with demographic, lifestyle, health, disease severity, and voice use factors.RESULTS: The prevalence of a current voice disorder in individuals with SS was 59.4%. In general, voice disorders began gradually; were chronic; and correlated with SS disease severity independent of age, sex, duration of the disease, comorbid autoimmune conditions, and use of SS-related medication. Specific voice symptoms including chronic throat dryness and soreness were significantly associated with SS disease severity.
引自：Pierce JL, Tanner K, Merrill RM, Miller KL, Ambati BK, Kendall KA, Roy N. Voice disorders in Sjögren's syndrome: Prevalence and related risk factors. Laryngoscope, 2014.© 2014 The American Laryngological, Rhinological and Otological Society, Inc. （注：干燥综合症病人或亲属可加QQ群交流，群号： 118194945 ，本网站站长私人微信号： ssgzz88 ）